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KMID : 0361620150500040333
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Journal of the Korean Orthopaedic Association
2015 Volume.50 No. 4 p.333 ~ p.336
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Nicolau Syndrome Following Intramuscular Diclofenac Injection
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Ahn Seong-Jun
Kim Bu-Hwan
Song Moo-Ho
Yoo Seong-Ho
Kim Yeong-Joon
Kang Suk-Woong
Kim Dong-Hwan
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Abstract
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Nicolau syndrome is a rare complication causing severe pain and tissue necrosis after intramuscular injection. In Korea, the Korea Dermatological Association has reported 12 cases, and some severe cases required surgical treatment. Most cases have been related to the administration of a variety of drugs, including nonsteroidal anti-inflammatory drugs, corticosteroids, and antibiotics. We present two patients who developed this complication, 1 case of typical Nicolau syndrome and 1 case of atypical Nicolau syndrome.
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KEYWORD
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intramuscular injection, nonsteroidal anti-inflammatory drugs (NSAIDs), Nicolau syndrome
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